In our lab we aim to understand the regulatory principles and underlying sequence determinants of transcription regulation in the developing vertebrate embryo and in disease states such as cancers. We apply functional genetic analysis, genomics technologies and computational biology tools. We exploit the transparency of the fish embryo in visualising developmental processes and gene expression and adapt them to organoid models.  

 

The Mueller lab is located in the Department of Cancer and Genomic Sciences at the and member of the Birmingham Centre for Genome Biology. We collaborate with colleagues in the College of Medicine and Health and College of Life Sciences and many external collaborators (Hyperlink) in applying zebrafish and various organoids models for studying genetic basis of development and cancers. Funding for our work has been received from H2020 programmes of the European Commission, HU-RIZON, BBSRC and the Wellcome Trust.